https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:522 Thu 25 Jul 2013 09:10:26 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53981 Thu 25 Jan 2024 12:57:12 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:1661 Sat 24 Mar 2018 08:30:27 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:1172 Sat 24 Mar 2018 08:28:29 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:28354 Escherichia coli, complete unlinking of newly replicated sister chromosomes is required to ensure their proper segregation at cell division. Whereas replication links are removed primarily by topoisomerase IV, XerC/XerD-dif site-specific recombination can mediate sister chromosome unlinking in Topoisomerase IV-deficient cells. This reaction is activated at the division septum by the DNA translocase FtsK, which coordinates the last stages of chromosome segregation with cell division. It has been proposed that, after being activated by FtsK, XerC/XerD-dif recombination removes DNA links in a stepwise manner. Here, we provide a mathematically rigorous characterization of this topological mechanism of DNA unlinking. We show that stepwise unlinking is the only possible pathway that strictly reduces the complexity of the substrates at each step. Finally, we propose a topological mechanism for this unlinking reaction.]]> Sat 24 Mar 2018 07:25:12 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:3443 Sat 24 Mar 2018 07:20:29 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:39721 Fri 17 Jun 2022 17:38:04 AEST ]]>